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Besides, monoamine neurotransmitters, DA, NE, and 5-HT, were depleted in PTZ-kindled rats

In addition to the classical ferroptosis pathway with GPX4 as the core described by Stockwell, some studies also proposed GPX4-independent pathways, such as ferroptosis regulated by p53 ( Figure 1 2.1 Important process of ferroptosis 2.1.1 Iron accumulation Ferric ions (Fe 3+ ) bind to transferrin (TF) in the blood circulation and the complex can then be transferred into the endosomes inside the cells via transferrin receptor 1 (TfR1) on the cell membrane

pept-1 Caenorhabditis elegans into extreme longevity

IHC revealed decreased -synuclein protein levels, indicating reduced neuronal damage, and increased brain-derived neurotrophic factor (BDNF) levels, confirming neuroprotection